The typical Celebrex dosage for acute short-term pain , such as back pain , in adults is mg for the first dose. This is followed by a second dose of mg after 8 to 12 hours, if needed. After this, the typical dosage is mg twice a day, as needed. The typical Celebrex dosage for osteoarthritis in adults is mg a day. This can be taken as a single dose or as mg twice a day. The typical Celebrex dosage for rheumatoid arthritis in adults is to mg twice a day.
The typical dosage for ankylosing spondylitis in adults is mg a day. If you still have pain after 6 weeks, your doctor may recommend increasing the dosage to mg a day. But if you still have pain after 6 weeks of taking this dose, Celebrex is unlikely to work for you. Your doctor will likely recommend an alternative treatment. The typical Celebrex dosage for primary dysmenorrhea period pain or menstrual cramps in adults is the same as for acute pain. Celebrex is approved to treat JRA in children ages 2 years and older.
If you miss a dose of Celebrex, take it as soon as you can. This can include setting an alarm on your phone or downloading a reminder app. A kitchen timer can work, too. Celebrex is taken on a short-term basis to relieve acute pain, such as back pain or menstrual cramps.
But you may take Celebrex on a long-term basis for chronic conditions such as arthritis , if your doctor determines this is safe for you. Celebrex should be taken at the lowest possible dose for the shortest possible time. Be sure to take Celebrex only as directed by your doctor. Celebrex can interact with several other medications. Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works.
Other interactions can increase the number of side effects or make them more severe. Below are certain medications that can interact with Celebrex. Before taking Celebrex, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.
Doing so can increase your risk of serious digestive problems. But in general, you should avoid any medications that contain the drugs listed above while using Celebrex. A boxed warning alerts doctors and patients about drug effects that may be dangerous. Blood thinners are drugs that are used to treat or help prevent dangerous blood clots in your body.
Taking Celebrex with blood thinners can raise your risk of bleeding, especially in your stomach or intestines. A clinical study assessed the risk of serious digestive problems in people who took Celebrex with low-dose aspirin.
Over 9 months, ulcers, bleeding, or perforations in the stomach or intestines occurred in:. If you do take Celebrex with one of these drugs, be sure to see your doctor right away if you have any signs of bleeding in your stomach or intestines. Corticosteroids are drugs used to reduce inflammation swelling and damage. Taking corticosteroids with Celebrex can raise your risk of serious digestive problems.
If you need to take a corticosteroid with Celebrex, be sure to see your doctor right away if you have any symptoms of digestive problems. Celebrex can sometimes raise blood pressure. Taking Celebrex with certain blood pressure medications can make these medications less effective at controlling your blood pressure. Examples of blood pressure medications that could be made less effective when taken with Celebrex include:.
If you need to use blood pressure medication with Celebrex, your doctor will regularly check your blood pressure. Taking Celebrex with diuretics, ACE inhibitors, or angiotensin II blockers can also raise your risk of kidney problems. If you need to take one of these drugs with Celebrex, you should be sure to drink plenty of fluids. Also, your doctor will do various tests to monitor your kidneys. Taking Celebrex with certain antidepressants can raise your risk of bleeding, especially in your stomach or intestines.
Taking Celebrex with digoxin can increase the level of digoxin in your body. This can increase your risk of digoxin side effects. If you need to take digoxin with Celebrex, your doctor will monitor your digoxin level.
Taking Celebrex with lithium can increase the level of lithium in your body. This can increase your risk of lithium side effects. If you need to take lithium with Celebrex, your doctor will monitor your lithium level. Taking Celebrex with methotrexate can increase your risk of methotrexate side effects. If you need to take methotrexate with Celebrex, be sure to tell your doctor if any side effects become more severe or if you develop new ones. Your doctor will monitor you closely and adjust your treatment if needed.
The drug is also used to treat RA and psoriasis. Taking Celebrex with cyclosporine can increase your risk of kidney problems. If you need to take cyclosporine with Celebrex, your doctor will monitor your kidney function and adjust your treatment as needed. Taking Celebrex with pemetrexed can increase your risk of pemetrexed side effects. If you need to take pemetrexed with Celebrex, be sure to tell your doctor if any side effects become more severe or if you develop new ones.
Fluconazole Diflucan is an antifungal drug. Taking Celebrex with fluconazole can reduce the breakdown of Celebrex in your body. This could increase the level of Celebrex and raise your risk of Celebrex side effects. Rifampin Rifadin is an antibiotic drug. Taking Celebrex with rifampin could increase the breakdown of Celebrex in your body. This could lower the level of Celebrex and make it less effective. However, you should still check with your doctor or pharmacist before using any of these products while taking Celebrex.
If you have any questions about eating certain foods with Celebrex, talk with your doctor. However, drinking alcohol with Celebrex could raise your risk of certain side effects, such as nausea, indigestion upset stomach , headache , and dizziness.
Keep in mind that taking Celebrex can increase your risk of ulcers slow healing sores and bleeding in your stomach and intestines. If you drink alcohol, talk with your doctor about how much is safe for you to drink while you take Celebrex. Other drugs are available that can treat your condition.
Some may be a better fit for you than others. They can tell you about other medications that may work well for you. Note: Some of the drugs listed here are used off-label to treat these specific conditions. Examples of other drugs that may be used to treat osteoarthritis include:. Examples of other drugs that may be used to treat rheumatoid arthritis include:.
Examples of other drugs that may be used to treat juvenile rheumatoid arthritis include:. Examples of other drugs that may be used to treat ankylosing spondylitis include:. Examples of other drugs that may be used to treat primary dysmenorrhea menstrual cramps include:. Not according to the manufacturer of Celebrex, but in practice, this can be a slightly gray area. Celebrex contains a sulfonamide medication. However, some research suggests that not every medication that contains a sulfonamide will trigger an allergic reaction in people with a sulfa allergy.
So in some cases, your doctor might consider prescribing Celebrex. But the decision would be made on a case-by-case basis. Blood thinners are drugs that are used to help prevent blood clots.
NSAIDs are used to treat pain and inflammation swelling and damage. To relieve pain, you should take Celebrex at the lowest possible dose for the shortest possible time. For example, to treat acute short-term pain, like menstrual cramps , back pain , or pain following surgery, you may need to take Celebrex only for a few days or weeks.
However, if you have a chronic long-term condition like arthritis , you might need to take Celebrex on a long-term basis. You should do this only if your doctor considers it safe for you to do so. Taking Celebrex for long periods of time can raise the risk for serious side effects. These include heart attack , stroke , and ulcers , or bleeding in your stomach or intestines. If you do take Celebrex for a long period of time, your doctor will also typically prescribe a medication to help protect your digestive system.
For example, tell your doctor if you still have pain after taking mg of Celebrex a day for 2 weeks. And if you have ankylosing spondylitis , tell your doctor if you still have pain after taking mg of Celebrex a day for 6 weeks.
Your doctor may recommend increasing your dosage or suggest a different treatment. In some cases it can be safe. These can include codeine, dihydrocodeine, hydrocodone , and oxycodone Percocet. These include ulcers and bleeding in your stomach and intestines. If you need to take another pain reliever while taking Celebrex, talk with your doctor first. They can suggest the most appropriate way to manage your pain. No, Celebrex has never been taken off the market. Two similar pain relievers, called rofecoxib Vioxx and valdecoxib Bextra , were withdrawn from the market in and And the FDA considered the risks of these drugs to outweigh their benefits.
A class of drugs is a group of medications that act in a similar way. So after Vioxx and Bextra were withdrawn from the market, a large clinical study was carried out to check the safety of Celebrex.
Researchers found that the risks of heart attack and stroke with Celebrex were much lower than with Vioxx or Bextra. The study also found that the risks were lower with Celebrex than with high doses of naproxen or ibuprofen. Over a month period, 2. This was compared with 2. Based on these results, the FDA decided that benefits of Celebrex outweigh its risks.
It reduces inflammation and relieves pain for various conditions. Celebrex is used to treat certain forms of arthritis as well as acute pain, including menstrual cramps. If you have damage to tissues in your body, such as following an injury or surgery, or due to arthritis, your body makes prostaglandins. These are hormones created by an enzyme called cyclooxygenase COX.
Prostaglandins are made as part of the healing process, but they also cause inflammation and pain. Prostaglandins are also responsible for causing your uterus to contract during your menstrual period. The contractions cause the lining of the uterus to be expelled, and they also cause menstrual cramps. Celebrex works by stopping COX from making prostaglandins. This reduces inflammation and relieves pain.
Celebrex starts to work soon after you start taking it. The drug can typically relieve acute pain like menstrual cramps or pain following surgery within 60 minutes of you taking a dose. The anti-inflammatory effect of Celebrex takes a little longer.
If you have arthritis, you may need to take Celebrex for a few days before the full effect is reached. However, in clinical studies , Celebrex was found to significantly reduce osteoarthritis pain within 24 to 48 hours of starting treatment. Certain pain -relieving drugs have a high potential for misuse. This can sometimes lead to addiction or dependence on these drugs and withdrawal symptoms when you stop taking them.
Drugs that are associated with these problems are primarily opioid pain relievers, such as codeine, oxycodone OxyContin , and hydrocodone Percocet. Opioids are sometimes known as narcotics. Due to their potential for misuse and dependence, these drugs are controlled substances. These laws help ensure that these drugs are used safely. If you have concerns about withdrawal or dependence for any medications you take, including Celebrex, talk with your doctor. You may wonder how Celebrex compares with other medications that are prescribed for similar uses.
Here we look at how Celebrex and ibuprofen are alike and different. Celebrex is a brand-name drug that contains celecoxib. Ibuprofen is a generic drug. Ibuprofen is also available under several brand names, including Ibu-Tab, Advil, and Motrin. The drug is available only by prescription. Ibuprofen comes as a tablet, capsule, and liquid suspension that you swallow. These forms of the drug can be taken up to four times a day. Ibuprofen also comes as an infusion. They can give this form of ibuprofen up to four times a day.
Ibuprofen is available OTC and by prescription. OTC brands of ibuprofen include Advil and Motrin. Higher doses of ibuprofen are available only by prescription under brand names such as Ibu-Tab. Celebrex contains celecoxib and belongs to a group of medicines called coxibs which are used to relieve pain and inflammation in a number of conditions.
The mechanism of action of celecoxib is believed to be due to inhibition of prostaglandin synthesis, primarily by inhibition of COX COX-2 is induced in response to inflammatory stimuli.
This leads to the synthesis and accumulation of inflammatory prostanoids, in particular prostaglandin E2, causing inflammation, oedema and pain. The active ingredient in Celebrex is celecoxib. It also contains other ingredients such as lactose monohydrate, sodium lauryl sulfate, povidone, croscarmellose sodium, magnesium stearate, gelatin, titanium dioxide, iron oxide yellow CI mg capsule , and indigo carmine CI mg capsule.
Ask your doctor or pharmacist if any of this applies to you. Celebrex may not be suitable for you if any of the conditions below apply to you. Do not take Celebrex if the expiry date printed on the packaging has passed, even though the capsules may look alright. If you take this medicine after the expiry date has passed, it may not work as well. Do not take Celebrex if the packaging is torn or shows signs of tampering.
If you have not told your doctor or pharmacist about these things, tell them before you start taking Celebrex. Tell your doctor or your pharmacist if you are taking any other medicines, including medicines you buy without a prescription from a pharmacy, supermarket or health food shop. Your doctor may need to adjust the dosage of these medicines or provide additional advice if you are also taking Celebrex.
Follow all directions given to you by your doctor and pharmacist carefully. They may differ from the information here. Your doctor may increase the dose to mg twice a day for a short period of time if you have a flare up. You may take Celebrex for up to 5 days. Take your medicine at about the same time each day. Taking it at the same time each day will have the best effect. It will also help you remember when to take it. If you need to take an antacid, take it at least 2 hours before or 2 hours after your dose of Celebrex.
Keep taking Celebrex for as long as your doctor advises. Do not exceed the dose recommended by your doctor.
Your risk of developing heart or blood vessel diseases e. If you need to take Celebrex for a long time see your doctor for regular check-ups so that they can monitor your condition and treatment. If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to. Otherwise, take it as soon as you remember, then go back to taking your capsules as you would normally. Immediately telephone your doctor or Poisons Information Centre telephone 13 11 26 for advice, or go to Accident and Emergency at your nearest hospital if you think you or anyone else may have taken too much Celebrex.
Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention. If you take too much Celebrex, you may feel tired, drowsy, sick, vomit, and have stomach pain.
You may also have difficulty breathing and feel faint. If you are about to start any new medicines, tell your doctor and pharmacist that you are taking Celebrex. If you develop any skin rash e. The onset of these events, if they occur, can occur at any time, but most often occur in the first month of treatment. Keep your capsules where young children cannot reach them. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.
Do not store it, or any other medicine, in the bathroom or near a sink. Do not leave it in the car or on window sills. Heat and dampness can destroy some medicines. NSAIDs and some other medicines can interact with each other and cause serious side effects. Keep a list of your medicines to show to your healthcare provider and pharmacist.
NSAID medicines should not be used by pregnant women late in their pregnancy. Talk to your doctor. Celebrex and Pregnancy Back to Top. Tell your doctor if you are pregnant or plan to become pregnant. Celebrex and Lactation Back to Top. Celebrex Usage Back to Top. Take Celebrex capsules by mouth at the same time each day. Celebrex is usually taken once or twice daily.
This medication can be taken with or without food. Swallow Celebrex capsules whole. Do not break, chew, or crush capsules. For people who have difficulty swallowing capsules, the contents of a Celebrex capsule can be added to applesauce.
Carefully empty the entire capsule contents onto a level teaspoon of cool or room temperature applesauce and swallow right away with water. To get the most benefit from Celebrex, take it exactly as prescribed by your doctor. Do not stop taking Celebrex without discussing it with your doctor. Celebrex Dosage Back to Top.
Osteoarthritis For relief of the signs and symptoms of OA the recommended oral dose is mg per day administered as a single dose or as mg twice daily. Rheumatoid Arthritis. Juvenile Rheumatoid Arthritis. Ankylosing Spondylitis AS. Management of Acute Pain and Treatment of Primary Dysmenorrhea The recommended dose of Celebrex is mg initially, followed by an additional mg dose if needed on the first day.
Celebrex Overdose Back to Top. Other Requirements Back to Top. Store this medication in the original, tightly sealed container. Keep Celebrex at room temperature, away from excess heat and moisture.
Keep this and all medications out of the reach of children. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk. Celebrex is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft CABG surgery.
Gastrointestinal Risk. NSAIDs, including Celebrex, cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms.
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